This is one of the hardest situations you can get in with respect to a successful career, getting laid off without any jobs available for you. Many have lost jobs across the world and not many companies are hiring, in fact they are continuing to trim down their workforce to save some more and allow them to get through the recession. If you happen to have a sizable amount in savings, why not consider going back to school.
You improve your skills and get a better bargaining chip with employers when the economy does spring back to life and mass hiring starts. You can even earn a little cash by doing some freelance work over the internet as an author or contributor to some blogs or other sites. That way, you pass the time without much of the idleness that tends to bring on depression which is bad for your health.